Small intestinal structure and passive permeability in systemic sclerosis.

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Small intestinal structure and passive permeability in systemic sclerosis.

Seventeen patients with proven systemic sclerosis had a peroral jejunal biopsy performed. Four biopsies were regarded as showing abnormalities, which were mostly confined to the deeper structures, although in two there was a minimal degree of villous atrophy without epithelial cell changes. Passive intestinal permeability, as assessed by the cellobiose/mannitol test, was normal in all patients....

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The permeability of the human small intestine has been studied by measuring the clearance from the plasma into the intestinal lumen of substances with molecular weights ranging from 60 to 80 000. A direct relationship has been demonstrated between intestinal loss and plasma concentration and an inverse one between clearance and molecular size.The permeability of the rabbit small intestine has b...

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Treatment of small intestinal disease in systemic sclerosis with octreotide: a prospective study in seven patients.

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ژورنال

عنوان ژورنال: Gut

سال: 1980

ISSN: 0017-5749

DOI: 10.1136/gut.21.4.293